Bionorte em Números
Artigo Publicado
| Ano do artigo | 2016 |
| Descrições/informações adicionais | Diabetes mellitus is a chronic and severe metabolic dysfunction, it?s slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim ofthis study was to evaluate the antidiabetic effect of hydroethanolic extract and granulated of Calophyllum brasiliense Cambess., Clusiaceae, species in diabetic rats as well as it?s biochemical parameters. The results demonstrated that both the pharmaceutical forms, hydroethanolic extract and granulated, were able to reduce significantly (p < 0.001) hyperglycemia and glycosuria, in addition to improve polydipsia, polyuria, and weight loss. Treatments using hydroethanolic extract and granulated were also able to reduce significantly levels of triacylglycerides, cholesterol and low-density lipoprotein, as well as the transaminases, urea and creatinine levels. Therefore, it is concluded that these pharmaceutical forms have anti-diabetic effect and act improving the biochemical parameters, this effect is probably due to the high content of polyphenolic compounds found in the formulations. |
| Descrições/informações adicionais(EN) | Diabetes mellitus is a chronic and severe metabolic dysfunction, it?s slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim ofthis study was to evaluate the antidiabetic effect of hydroethanolic extract and granulated of Calophyllum brasiliense Cambess., Clusiaceae, species in diabetic rats as well as it?s biochemical parameters. The results demonstrated that both the pharmaceutical forms, hydroethanolic extract and granulated, were able to reduce significantly (p < 0.001) hyperglycemia and glycosuria, in addition to improve polydipsia, polyuria, and weight loss. Treatments using hydroethanolic extract and granulated were also able to reduce significantly levels of triacylglycerides, cholesterol and low-density lipoprotein, as well as the transaminases, urea and creatinine levels. Therefore, it is concluded that these pharmaceutical forms have anti-diabetic effect and act improving the biochemical parameters, this effect is probably due to the high content of polyphenolic compounds found in the formulations. |
| Divulgação científica | NAO |
| DOI | 10.1016/j.bjp.2016.04.004 |
| Homepage do trabalho | [doi:10.1016/j.bjp.2016.04.004] |
| Idioma | Inglês |
| ISSN | 0102695X |
| Meio de divulgação | MEIO_DIGITAL |
| Natureza | COMPLETO |
| Página final | 2727 |
| Página inicial | 2721 |
| Relevânica | NAO |
| Sequencia da produção | 736 |
| Título do artigo | Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin |
| Título do artigo(EN) | Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin |
| Título do periódico ou revista | Revista Brasileira de Farmacognosia (Impresso) |
| Volume | 26 |
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