Detalhes da Oferta

Histórico, estrutura e função: CRISPR como um sistema imune adaptativo de microrganismos; evidências experimentais. Classificação evolutiva dos sistemas CRISPR-Cas. Genes de bacteriófagos que inativam o sistema imune CRISPR/Cas bacteriano. Identificação e reconstrução de CRISPR-Cas a partir de dados metagenômicos. Estudos do sistema CRISPR-Cas in vitro. Edição genômica em células de mamíferos. Edição genômica terapêutica: perspectivas, desafios e questões éticas.

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David Burstein, Lucas B. Harrington, Steven C. Strutt, Alexander J. Probst, Karthik Anantharaman, Brian C. Thomas, Jennifer A. Doudna & Jillian F. Banfield (2017) New CRISPR%u2013Cas systems from uncultivated microbes.